Grapefruit juice should not be contraindicated in people taking statins. Notes for Professionals: Avoid grapefruit juice quantities greater than 1.2 L daily in patients taking atorvastatin to avoid the potential for drug accumulation. While grapefruit is a go-to healthy snack for many people, it contains a chemical called furanocoumarins which prevents enzymes in the body called CYP3A from breaking down certain types of statins. The increased rhabdomyolysis risk from grapefruit juice consumption due to the increased effective statin dose is minimal compared with the greater effect in preventing heart disease. If the juice is taken 12 hours before these statins, the reductions are, respectively, 43% and 66%, and for atorvastatin, 42% and 66%. When simvastatin or lovastatin are taken at the same time as grapefruit juice, the estimated reduction in LDL cholesterol is 48%, and in heart disease is 70%. Simvastatin 40 mg, lovastatin 40 mg, and atorvastatin 10 mg daily reduce low-density lipoprotein (LDL) cholesterol levels in a 60-year-old man with an LDL cholesterol of 4.8 mmol/L by 37%, reducing ischemic heart disease risk by 61%. Several sources report eating as little as one grapefruit can cause issues. However, how much grapefruit juice one needs to consume to produce a clinically significant drug interaction isn't entirely known. A daily glass of grapefruit juice increases blood levels of simvastatin and lovastatin by about 260% if taken at the same time (about 90% if taken 12 hours apart), and atorvastatin by about 80% (whenever taken). It has been fairly well documented that grapefruit juice can interact with several drugs, including Lipitor ( atorvastatin ), a 'statin' medication used to lower cholesterol. The medications affected by grapefruit include certain statins, which are used to treat high cholesterol. Having large quantities of grapefruit while taking simvastatin or atorvastatin can increase your risk of side effects. Furanocoumarins are present in many different plants, including grapefruit, and they have the ability to deactivate the CYP3A4 enzyme. Grapefruit is a common food that has this effect with statins. Grapefruit and grapefruit juice interact with statins through an organic chemical compound called furanocoumarins. As healthy as grapefruit is, people taking certain medications shouldn’t mix grapefruit with their prescriptions. Which medications or foods do statins interact with Some medicines and foods affect the way your liver can process the statin, increasing the risk of side effects.
5 Cyclosporine: This drug is an immunosuppressant and is usually prescribed to patients who have undergone organ transplant. We determined the validity of current medical advice to avoid grapefruit juice consumption while taking 3 widely used statins. Grapefruit is undeniably healthy - it’s packed with vitamins, minerals, antioxidants and fiber that your body needs. Specific statins that react with grapefruit include simvastatin 3 and atorvastatin 4 Nifedipine: It is used to treat high blood pressure and angina (chest pain) and having it with grapefruit could result in increased absorption.
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